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Caspase-1 cleavage

There are 9 papers on caspase-1 cleavage in aging research: none in people yet, 7 in animals, 2 in cells. The newest story, Nov 9, 2026: “Gut microbe-derived compound promotes kidney aging in mice”.

Biomarker

9 papers study it1 more mentions it1 finding

1 new paper in 30 daysSee all 10 papers on caspase-1 cleavage

  • Animals7
  • Cells2

Interventions

1

Nicotinamide mononucleotide

downin mouse cells1

1 study

  1. Nicotinamide mononucleotide decreases caspase-1 cleavage in FK866-treated macrophages.

    “restoration of NAD+ level by supplementation with nicotinamide mononucleotide abrogated the FK866-mediated caspase-1 cleavage”

    Cellsin FK866-treated macrophages

    Intracellular NAD⁺ Depletion Confers a Priming Signal for NLRP3 Inflammasome Activation

    Frontiers in immunology

More on Nicotinamide mononucleotide

Latest

Dec 2025: 0Jan 2026: 0Feb 2026: 1Mar 2026: 0Apr 2026: 0May 2026: 0Jun 2026: 0Jul 2026: 0Aug 2026: 0Sep 2026: 0Oct 2026: 0Nov 2026: 12 papers in 12 months
Renal Failure

Gut microbe-derived compound promotes kidney aging in mice

Reducing a circular RNA weakened the compound’s effects in male mice given it in drinking water for 16 weeks.Reducing a circular RNA weakened the compound’s effects in male mice given it in drinking water for 16 weeks.

Mouse studyKidney
Paper

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