Casp3

1 paper

Animals1

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8 in 12 months

Biogerontology26 Sep

Erigeron breviscapus extends lifespan in worms

Treatment prolonged average lifespan up to a maximum of 18.68% while enhancing stress resistance and motor function in the roundworms.Treatment prolonged average lifespan up to a maximum of 18.68% while enhancing stress resistance and motor function in the roundworms.

Experiments in wormsInterventions

Diabetes, Obesity & Metabolism22 Sep

Comparative Risk of Nonarteritic Anterior Ischemic Optic Neuropathy Among Glucagon-Like Peptide-1 Receptor Agonists: An Integrated Safety and Mechanistic Analysis

Meta-analysis of studies in peopleGLP-1 receptor agonists

International Journal of Clinical and Experimental Pathology13 Sep

Arterial origin-dependent susceptibility of vascular smooth muscle cells to prelamin A-induced senescence and rescue by umbilical artery-derived decellularized extracellular matrix

Experiments in human cellsCellular senescence

Metabolic Brain Disease11 Sep

Neuroprotective impact of nicotinamide riboside and metformin on the hippocampus of male rats with diet-induced obesity

Experiments in ratsNicotinamide riboside

PLOS One5 Aug

FAERS-based pharmacovigilance and network toxicology analysis of esomeprazole-associated osteoporosis

Computational studyOsteoporosis

Reproductive Toxicology13 May

FSH mediated endocrine disruption potential of Dibutyl phthalate in cultured ovine ovarian granulosa cells: Cytotoxicity, oxidative stress, steroidogenesis, cell senescence, and expression of related key developmental genes

Experiments in cellsOxidative stress and ROS signalling

bioRxiv18 Mar

Two Stages of Dynamic Metabolic and Transcriptomic Remodeling During the Adaptation to Caloric Restriction in Male C57BL/6J

Preprint: experiments in miceDietary restriction

Translational Oncology7 Jan

First functional evidence that a rare germline TP53β variant drives senescence-associated immune suppression and impairs apoptosis and cell migration in breast cancer patients

Cohort study in peopleApoptosis

Frontiers in Immunology15 Sep

Integrative transcriptomic and machine learning analyses identify HDAC9 as a key regulator of mitochondrial dysfunction and senescence-associated inflammation in diabetic nephropathy

Experiments in human cellsCellular senescence

Biomedical Reports21 Jan

Age‑related changes in endoplasmic reticulum stress response‑associated protein expression in rat tibial nerves

Experiments in animalsMechanisms