Cardiovagal baroreflex sensitivity

1. Antioxidant supplementation improves cardiovagal baroreflex sensitivity in young adults with high total sleep time irregularity and chronic anxiety.

   “Following antioxidant supplementation, oxidative stress and blood pressure control were significantly improved in the high TSTI group”

   Human trialin young adults with high total sleep time irregularity and chronic anxiety

   Examining oxidative stress as a mechanistic link between sleep irregularity and cardiovascular risk in young adults with chronic anxiety

   American journal of physiology. Heart and circulatory physiology·Feb 25, 2026

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1. Early menopause onset is linked with lower cardiovagal baroreflex sensitivity in humans (early menopause onset (<=49 years) vs late onset (>=53 years)) (6.30±2.76 ms/mmHg vs. 9.42±4.68 ms/mmHg, P< 0.05).

   “the early onset group had lower cvBRS compared to the late onset group (6.30±2.76 ms/mmHg vs. 9.42±4.68 ms/mmHg; P< 0.05).”

   Humansearly menopause onset (<=49 years) vs late onset (>=53 years)females

   Impact of Age at Menopause on Autonomic Cardiovascular Function

   Physiology·May 1, 2026

1. Sleep efficiency irregularity is associated with cardiovagal baroreflex sensitivity in humans (PTSD).

   “Greater SE irregularity was significantly associated with higher oxidative stress and reduced cBRS in the PTSD group”

   HumansPTSD7 daysn = 28

   Sleep Efficiency Irregularity Links PTSD with Early Cardiovascular Dysfunction in Young Adults

   American journal of physiology. Regulatory, integrative and comparative physiology·Nov 6, 2026

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1. IL-6 is associated with cardiovagal baroreflex sensitivity in humans (r = -0.594, P = 0.007).

   “inversely correlated with cBRS (r = -0.594, P = 0.007)”

   Humansmales

   Age-associated reductions in cardiovagal baroreflex sensitivity are exaggerated in middle-aged and older men with low testosterone

   Journal of applied physiology (Bethesda, Md. : 1985)·Jun 30, 2022

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1. Testosterone is associated with cardiovagal baroreflex sensitivity in humans (low testosterone vs normal testosterone) (5.5 ± 3.2 vs 10.7 ± 4.0 ms/mmHg, P = 0.039).

   “middle-age/older men with low testosterone had lower cBRS (5.5 ± 3.2 ms/mmHg; P = 0.039) compared with age-matched men with normal testosterone”

   Humanslow testosterone vs normal testosteronemales

   Age-associated reductions in cardiovagal baroreflex sensitivity are exaggerated in middle-aged and older men with low testosterone

   Journal of applied physiology (Bethesda, Md. : 1985)·Jun 30, 2022

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