Aging Cell
Tiny packages promote calcium buildup in lab-grown human valve cells
Experiments in human valve cells found that Gas6, a protein, helped release tiny packages that promoted calcium deposits in other valve cells.Experiments in human valve cells found that Gas6, a protein, helped release tiny packages that promoted calcium deposits in other valve cells.
Experiments in human cellsMechanisms
What changedCalcium buildup was greater in valve cells given vesicles from calcified valves than those given vesicles from noncalcified valves
The catchThe specific molecular cargo of the vesicles was not fully characterized