International Journal of Molecular Medicine·Jul 25Dulaglutide markedly prevents peritoneal fibrosis in a rodent model of chronic kidney disease: Insights into the pathogenesisExperiments in ratsDulaglutidePaper
bioRxiv·Jul 16Donor Age Impairs Vasculogenic Potential of hiPSC-Derived Endothelial ProgenitorsPreprint: experiments in human cellsMechanismsPaper
bioRxiv·Jul 14IsoDGR-Induced Endothelial Cytoskeletal Disruption Drives Age-Related Blood-Brain Barrier BreakdownPreprint: experiments in miceInterventionsPaper
Cell Reports·Jun 12Deficiency in N-cadherin-Akt3 signaling impairs the blood-brain barrierStudy in peoplePI3K–AKT signalingPaper
Metabolites·May 27Dietary Nicotinamide Mononucleotide, a Key NAD⁺ Intermediate, Alleviates Body Fat Mass and Hypertriglyceridemia by Enhancing Energy Expenditure with Promotion of Fat Oxidation and Hepatic Lipolysis and Suppressing Hepatic Lipogenesis in db/db MiceExperiments in miceNicotinamide mononucleotidePaper
PLOS One·May 16Inhibition of VE-PTP rejuvenates Schlemm's canal in aged mice and acts via Tie2Experiments in miceInterventionsPaper
Environment International·Apr 27Evaluating inhalation risks and toxicological impacts of lithium-ion battery thermal runaway emissionsExperiments in human cellsMechanismsPaper
Biomedicines·Apr 25SIRT1 Mediates the Effects of Sera from Athletes Who Engage in Aerobic Exercise Training in Activating Cells for Wound HealingStudy in peopleSirtuin signalingPaper
GeroScience·Apr 24Longitudinal changes in blood-borne geroscience biomarkers: results from a population-based studyCohort study in peopleBiomarkersPaper
Advanced Biology·Apr 8Activation of SIRT1 Reduces Renal Tubular Epithelial Cells Fibrosis in Hypoxia Through SIRT1-FoxO1-FoxO3-Autophagy PathwayExperiments in human cellsSirtuin signalingPaper
Investigative Ophthalmology & Visual Science·Apr 1NMN Supplementation Inhibits Endothelial Cell ROS-Mediated Src/Pi3k/Akt Signaling Pathway to Protect High-Altitude Blood-Retinal BarrierExperiments in miceNicotinamide mononucleotidePaper
Acta Biochimica et Biophysica Sinica·Feb 13Ageing-associated gut dysbiosis deteriorates mouse cognitionExperiments in miceGut and microbiomePaper
GeroScience·Jan 16Lung endothelial cell senescence impairs barrier function and promotes neutrophil adhesion and migrationStudy in peopleCellular senescencePaper
International Journal of Molecular Medicine·Jan 10Klotho attenuates epithelial‑mesenchymal transition of retinal pigment epithelial cells in subretinal fibrosis by suppressing the ERK1/2 and Wnt/β‑catenin signaling pathwaysExperiments in miceEyePaper
Aging Cell·Jan 9Weakened Airway Epithelial Junctions and Enhanced Neutrophil Elastase Release Contribute to Age-Dependent Bacteremia Risk Following Pneumococcal PneumoniaExperiments in miceMechanismsPaper
Georgian Medical News·Dec 27BREAST CANCER AND DIAGNOSTIC METHODS: UNDERSTANDING THE ROLE OF BRCA1 AND BRCA2ReviewBreast cancerPaper
bioRxiv·Nov 22Crosstalk in skin: Loss of desmoglein 1 in keratinocytes inhibits BRAFV600E-induced cellular senescence in human melanocytesPreprint: experiments in human cellsCellular senescencePaper
bioRxiv·Oct 17KLHDC7B, a novel gene associated with age-related hearing loss in humans, is required for the maintenance of hearing in micePreprint: experiments in miceEarPaper
Biomarker Research·Oct 15The spatial impact of a Western diet in enriching Galectin-1-regulated Rho, ECM, and SASP signaling in a novel MASH-HCC mouse modelExperiments in miceCell cycle regulationPaper
Journal of Cellular and Molecular Medicine·Oct 1Metformin represses the carcinogenesis potentially induced by 50 Hz magnetic fields in aged mouse fibroblasts via inhibition of NF-kBExperiments in mouse cellsMetforminPaper
BMC Geriatrics·Aug 26A (poly)phenol-rich diet reduces serum and faecal calprotectin in older adults with increased intestinal permeability: the MaPLE randomised controlled trialRandomized trial in 51 peopleGut and microbiomePaper
Folia Neuropathologica·Aug 21An enriched environment promotes cognitive recovery and cerebral blood flow in aged mice under sevoflurane anaesthesiaExperiments in miceInterventionsPaper
Biogerontology·Aug 20Dietary nitrate maintains intestinal epithelia homeostasis in aged miceExperiments in miceNitratePaper
Chemico-biological Interactions·Aug 10Metformin promotes the survival of random skin flaps via the activation of Nrf2/HO-1 signalingExperiments in 24 ratsMetforminPaper
International Journal of Biological Sciences·Aug 8NRF2-HIF2α Signaling Attenuates Endothelial Cell Senescence and Maintains Intercellular Junctions in DiabetesExperiments in human cellsInterventionsPaper
Oncology Reports·Aug 2Metformin suppresses esophageal cancer progression through the radiation‑induced cellular senescence of cancer‑associated fibroblastsExperiments in human cellsMetforminPaper
bioRxiv·Jun 3A Single-Short Partial Reprogramming of the Endothelial Cells decreases Blood Pressure via attenuation of EndMT in Hypertensive MicePreprint: experiments in micePartial reprogrammingPaper
Journal of Applied Toxicology·Apr 19Atorvastatin-induced intracerebral hemorrhage is inhibited by berberine in zebrafishExperiments in zebrafishBerberinePaper
Nature Communications·Apr 6The secreted protein Amuc_1409 from Akkermansia muciniphila improves gut health through intestinal stem cell regulationExperiments in miceGut and microbiomePaper
Free Radical Research·Mar 27Humanin inhibits lymphatic endothelial cells dysfunction to alleviate myocardial infarction-reperfusion injury via BNIP3-mediated mitophagyExperiments in miceInterventionsPaper