Brain aging
Biomarker1 paper1 finding
- Humans1
Upstream
1Menopause
upin humans1
1 study
Menopause
upin humans1
Menopause increases brain aging in humans.
Humansfemalesn = 2,814
Blood proteomics of menopause map to brain aging and dementia risk · Nature medicine · 22 Sep 2026
Funding
National Institute on AgingUS$29.1mNational Institute of Mental HealthUS$1.6mNational Institute on Drug AbuseUS$1.1m46 grants since 2006
Left Ventricular Dysfunction, Cognition, and Brain Aging in a Multi-Ethnic Cohort
National Institute on AgingColumbia University Health SciencesUS$194.4k2026–2031
Deep neural networks to map the pace of brain aging before Alzheimer's disease
National Institute on AgingUniversity of Southern CaliforniaUS$758.3k2026–2031
Perimenopause in Brain Aging and Alzheimer's Disease
National Institute on AgingUniversity of ArizonaUS$5.1m2006–2031
National Institute on AgingIcahn School of Medicine at Mount SinaiUS$133.1k2026–2028
The impact of metals and polygenic risk on multiomics, brain aging, and ADRD outcomes
National Institute on AgingUniversity of Michigan at Ann ArborUS$1.5m2024–2029
PRE3BAD: Preclinical Research on Emerging Environmental Exposures, Brain Aging, and Dementia
National Institute on AgingUniversity of New Mexico Health Scis CtrUS$1.9m2024–2029
National Institute on AgingBoston University Medical CampusUS$2m2024–2029
L1 retrotransposon contribution to normal brain aging and Alzheimers Disease in vivo
National Institute on AgingTulane University of LouisianaUS$420.8k2026–2028
Brain Aging in Adults with Autism Spectrum Disorder
National Institute of Mental HealthUniversity of California at DavisUS$43.5k2025–2027
Latest
271Three-region brain aging model better predicted death risk
A three-region model scored 0.81 versus 0.79 for a whole-brain model on a measure of how well it ranked death risk.A three-region model scored 0.81 versus 0.79 for a whole-brain model on a measure of how well it ranked death risk.
Gut metabolites linked to preserved brain thickness in older adults
In a 104-person trial sub-study, rising levels of gut-produced urolithins tracked with preserved cortical thickness over two years in 55 older adults…In a 104-person trial sub-study, rising levels of gut-produced urolithins tracked with preserved cortical thickness over two years in 55 older adults eating walnuts.
Protein deficiency impaired memory in aging mice
Experiments in 15-month-old mice with reduced Nipsnap1, a protein involved in cell maintenance, found reduced gene activity linked to nerve-cell…Experiments in 15-month-old mice with reduced Nipsnap1, a protein involved in cell maintenance, found reduced gene activity linked to nerve-cell signalling and increased activity linked to inflammation.
Brain age estimates were higher across six disorders
The gap between scan-estimated and actual age exceeded age-matched controls by 7.64 years in schizophrenia and 7.61 years in frontotemporal dementia.The gap between scan-estimated and actual age exceeded age-matched controls by 7.64 years in schizophrenia and 7.61 years in frontotemporal dementia.
Air pollution linked to faster brain tissue loss in adults
An observational study followed brain scans from 4,276 middle-aged and older adults, linking higher exposure to particle pollution with faster grey…An observational study followed brain scans from 4,276 middle-aged and older adults, linking higher exposure to particle pollution with faster grey matter loss.
Neuropeptide Y and brain ageing: an updated scoping review on the role of autophagy
Caloric restriction mimetics rewire the AMPK-mTOR-ULK1 signaling nexus to restore autophagic proteostasis in the aging brain
Healthy plant-rich diets linked to better olfactory function
In a cross-sectional study of 6,690 adults, healthy plant-rich eating patterns and specific foods like fruits and vegetables tracked with lower rates…In a cross-sectional study of 6,690 adults, healthy plant-rich eating patterns and specific foods like fruits and vegetables tracked with lower rates of hyposmia.