BBB junction protein expression

1 paper1 finding

Upstream

1

cGAS–STING signalling

downin reviews1

1 study

cGAS–STING signalling decreases BBB junction protein expression.
“the cGAS-STING pathway concurrently drives senescence maintenance, SASP induction and type I interferon (IFN-I)-mediated downregulation of BBB junction proteins”
Reviewvia type I interferon signalingblood-brain barrier
Neurovascular unit senescence as a driver of blood-brain barrier dysfunction in Alzheimer's disease：Mechanisms, consequences, and therapeutic implications
Ageing research reviews18 Jul 2026

More on cGAS–STING signalling

Latest

1 in 12 months

Ageing Research Reviews19 Jul

Neurovascular unit senescence as a driver of blood-brain barrier dysfunction in Alzheimer's disease：Mechanisms, consequences, and therapeutic implications

ReviewCellular senescence