Angiotensin II
Biomarker1 paper
- Human trial1
Funding
National Institute on AgingUS$1.5mNational Heart, Lung, and Blood InstituteUS$418.2k3 grants since 2017
National Institute on AgingAlbert Einstein College of MedicineUS$731.1k2026–2031
The Impact of Sex and Hippocampal Angiotensin II on Alzheimer's Disease
National Institute on AgingUniversity of North Texas Hlth Sci CtrUS$729.2k2024–2029
Cardiomyocyte TRPV4 and Angiotensin-II induced ventricular arrhythmia with aging
National Heart, Lung, and Blood InstituteUniversity of Missouri-ColumbiaUS$418.2k2017–2028
Latest
13RAS inhibitors linked to lower dementia risk than CCBs
Incidence of all-cause dementia was 1.26 per 1000 person-years with RAS inhibitors versus 1.89 with calcium channel blockers (HR 0.68).Incidence of all-cause dementia was 1.26 per 1000 person-years with RAS inhibitors versus 1.89 with calcium channel blockers (HR 0.68).
Lack of the AT2R receptor accelerates cardiac senescence and fibrosis in aging mice
Mice lacking the receptor also showed higher inflammation, elevated DNA damage, and a five-month reduction in median lifespan.Mice lacking the receptor also showed higher inflammation, elevated DNA damage, and a five-month reduction in median lifespan.