What does the research say about android-to-gynoid ratio?

Android-to-gynoid ratio

There are 5 papers on android-to-gynoid ratio in aging research: 5 observational studies in people. The newest story, Nov 2, 2026: “Fat distribution differs in symptom-free dementia mutation carriers”.

Biomarker

5 papers study it5 more mention it4 findings

See all 10 papers on android-to-gynoid ratio

“higher A/G ratio was associated with a higher risk of any fracture (HR: 1.28, 95% CI: 1.14-1.43) and osteoporotic vertebral fracture (HR: 1.19, 95% CI: 1.05-1.36).”

Sarcopenic obesity defined by visceral adiposity was associated with osteoporotic vertebral fractureArchives of osteoporosis2022doi:10.1007/s11657-022-01087-9

Humans5

Associations

Cortical, subcortical and thalamic volumes

downin humans1

1 study

Android-to-gynoid ratio is associated with cortical, subcortical and thalamic volumes in humans (asymptomatic C9orf72 expansion carriers).
“Lower android-to-gynoid ratio and lean mass were associated with lower volumes across the cortex, subcortex, and thalamus.”
Humansasymptomatic C9orf72 expansion carriersbrain
Fat distribution differs in symptom-free dementia mutation carriers
Alzheimer's & dementia : the journal of the Alzheimer's AssociationJul 1, 2026

More on Cortical, subcortical and thalamic volumes

C9ORF72EXPANSION

downin humans1

1 study

C9ORF72EXPANSION is associated with android-to-gynoid ratio in humans (asymptomatic carriers compared with non-carriers, average 11-12 years prior to onset).
“Changes in body composition were identified in the C9orf72 expansion carrier group compared to non-carrier group (average 11-12 years prior to onset): lower android-to-gynoid ratio (p = 0.009)”
Humansasymptomatic carriers compared with non-carriers, average 11-12 years prior to onset
Fat distribution differs in symptom-free dementia mutation carriers
Alzheimer's & dementia : the journal of the Alzheimer's AssociationJul 1, 2026

Latest

4 papers in 12 months

Annals of the American Thoracic SocietyJul 16

Frailty in Pulmonary Arterial Hypertension: A Cohort Study

Cohort study of 80 peoplePulmonary arterial hypertension

Paper

Alzheimer's & DementiaJul 15

Fat distribution differs in symptom-free dementia mutation carriers

Body scans compared 13 symptom-free mutation carriers with 27 non-carriers and found differences in fat distribution and fat around internal organs.Body scans compared 13 symptom-free mutation carriers with 27 non-carriers and found differences in fat distribution and fat around internal organs.

Cross-sectional studyFrontotemporal dementia