Amyloid plaque load

1. Particulate matter increases amyloid plaque load in rats (LDV+HDV PM exposure).

   “At 9 months, females exposed to LDV+HDV PM had increased amyloid plaques in the hippocampus”

   AnimalsLDV+HDV PM exposureLDV+HDV PMhippocampusfemales

   Traffic pollution accelerated brain plaque buildup in rats

   Neurotoxicology·May 26, 2026

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1. Rapamycin increases amyloid plaque load in mice (5xFAD mice).

   “This was associated with increased Aβ plaque load.”

   Animals5xFAD mice

   Rapamycin treatment reduces CD11c⁺ microglia and increases amyloid plaque load in 5xFAD mice

   Experimental neurology·Mar 18, 2026

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1. Focused ultrasound decreases amyloid plaque load in mice (3xTg-AD mice).

   “Amyloid plaque population, volume and overall load were also reduced overall.”

   Animals3xTg-AD micebrainFour weekly bilateral sonications4 weeks

   Focused ultrasound mitigates pathology and improves spatial memory in Alzheimer's mice and patients

   Theranostics·Jul 14, 2023

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1. Thymosin beta 4 decreases amyloid plaque load in LPS-treated APP/PS1 mice.

   “It prevented LPS-induced amyloid burden in APP/PS1 mice”

   Animalsin LPS-treated APP/PS1 micebrain5 mg/kg, i.v.malesn = 30

   Thymosin beta 4 prevents systemic lipopolysaccharide-induced plaque load in middle-age APP/PS1 mice

   International immunopharmacology·Mar 4, 2023

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1. Fecal microbiota transplantation increases amyloid plaque load in 5xFAD recipient mice after antibiotic pretreatment.

   “single brain regions (prefrontal cortex and dentate gyrus) showed higher plaque load after transfer of material from older animals”

   Animalsin 5xFAD recipient mice after antibiotic pretreatmentcecal material from 1-year-old wild-type donorsprefrontal cortex and dentate gyrusone-time transfer

   Impact of the Age of Cecal Material Transfer Donors on Alzheimer's Disease Pathology in 5xFAD Mice

   Microorganisms·Dec 9, 2021

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1. Paroxetine decreases amyloid plaque load in mice (APPswe/PS1dE9 transgenic mice).

   “Paroxetine treatment from 9 to 18months of age reduced hippocampal amyloidosis without affecting the number of neuroblasts or granular neurons.”

   AnimalsAPPswe/PS1dE9 transgenic micehippocampus9 months

   Neuron and neuroblast numbers and cytogenesis in the dentate gyrus of aged APPswe/PS1dE9 transgenic mice: Effect of long-term treatment with paroxetine

   Neurobiology of disease·Apr 28, 2017

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1. FBB retention is associated with amyloid plaque load in mice (autoradiography validation) (r Pearson = 0.947).

   “An excellent correlation between data derived from PET and autoradiography could be obtained (r Pearson = 0.947, p < 0.0001).”

   Animalsautoradiography validationbrain

   Comparison of the Amyloid Load in the Brains of Two Transgenic Alzheimer's Disease Mouse Models Quantified by Florbetaben Positron Emission Tomography

   Frontiers in neuroscience·Oct 4, 2021

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1. Florbetaben is associated with amyloid plaque load in mice (ARTE10 APP/PS1 mice).

   “Amyloid plaque load increased progressively with age in the cortex and hippocampus of ARTE10 mice, which could be detected with both in vivo FBB PET and ex vivo autoradiography.”

   AnimalsARTE10 APP/PS1 micecortex and hippocampus

   Comparison of the Amyloid Load in the Brains of Two Transgenic Alzheimer's Disease Mouse Models Quantified by Florbetaben Positron Emission Tomography

   Frontiers in neuroscience·Oct 4, 2021

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1. N-acetylaspartate is associated with amyloid plaque load in mice (PS2APP mice) (92% sensitivity and 82% specificity).

   “A diagnostic test, based on these measures, reached 92% sensitivity and 82% specificity at age 20 months.”

   AnimalsPS2APP micefrontal cortex

   Altered metabolic profile in the frontal cortex of PS2APP transgenic mice, monitored throughout their life span

   Neurobiology of disease·Feb 1, 2005

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