Amyloid-β plaque burden

1. Multiparity increases amyloid-β plaque burden in mice.

   “Multiparous 5xFAD mice showed increased Aβ plaque burden, elevated BACE1 expression, synaptic loss, and activated senescence pathways compared to nulliparous controls.”

   Animalsfour consecutive gestation cyclesbrainfemales

   Multiparity exacerbates Aβ accumulation and promotes cellular senescence in a mouse model of amyloidosis

   Immunity & ageing : I & A·29 Mar 2026

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1. Canagliflozin decreases amyloid-β plaque burden in mice.

   “Importantly, Cana treatment markedly reduced hippocampal Aβ plaque burden and attenuated neuroinflammation in male 5XFAD mice.”

   Animals5XFAD micediethippocampus180 ppmmales

   SGLT2i, Canagliflozin mitigates amyloid‐beta pathology and cognitive decline in 5XFAD mice

   AAIC 2025 abstract·26 Dec 2025

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1. GFAP is associated with amyloid-β plaque burden in dogs.

   “Plasma glial fibrillary acidic protein (GFAP) concentrations were positively correlated with Aβ plaque burden, whereas other biomarkers were not.”

   Animalsplasma and brainn = 24

   Alzheimer's disease neuropathological characterization of the dog brain and relationship to biofluid biomarkers and cognitive function

   NPJ dementia·6 Oct 2026

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1. Cognitive impairment is associated with amyloid-β plaque burden in dogs.

   “Quantitative analyses showed greater Aβ burden in cognitively impaired dogs”

   Animalsbrainn = 24

   Alzheimer's disease neuropathological characterization of the dog brain and relationship to biofluid biomarkers and cognitive function

   NPJ dementia·6 Oct 2026