Amygdala volume

1. Physical activity protects against amygdala volume in humans (β = -0.221 p ≤ 0.001).

   “That indicated LPA moderates ACEs-related structural changes in the amygdala, a key component of the central circuitry of emotion and stress sensitization.”

   Humansin individuals with adverse childhood experiencesamygdalan = 81

   The moderating effect of lifetime physical activity on brain alterations related to adverse childhood experiences

   European psychiatry : the journal of the Association of European Psychiatrists·20 Oct 2025

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1. Adverse childhood experiences increase amygdala volume in humans (β = -0.221 p ≤ 0.001).

   “Notably, only in individuals with low physical activity were ACEs associated with increased volume of amygdala.”

   Humanslow physical activityamygdalan = 81

   The moderating effect of lifetime physical activity on brain alterations related to adverse childhood experiences

   European psychiatry : the journal of the Association of European Psychiatrists·20 Oct 2025

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1. Social activity is associated with amygdala volume in humans.

   “increases in social activity with higher resilience and larger amygdala volume”

   Humansadjusted for age, sex, race, ethnicity, and educationn = 260

   Associations between self-reported change in lifestyle behaviors and brain health: Findings from the Healthy Brain Initiative

   Journal of Alzheimer's disease : JAD·19 Mar 2026

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