Memory composite score

Biomarker

6 papers1 finding

Humans6

Associations

LC MRI intensity

downin humans1

1 study

LC MRI intensity is associated with memory composite score in humans (P = .01).
“lower LC intensity was associated with worse memory at low (P = .01), but not high (P = .64) pTau217 levels.”
Humansat low pTau217 levels, adjusted for educationlocus coeruleusn = 127
Brainstem MRI signal links to an Alzheimer's marker in adults
medRxiv9 Oct 2026Preprint

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medRxiv9 Oct

Brainstem MRI signal links to an Alzheimer's marker in adults

Each standard deviation decrease in locus coeruleus intensity was associated with 53% higher odds of testing positive for an Alzheimer's blood marker.Each standard deviation decrease in locus coeruleus intensity was associated with 53% higher odds of testing positive for an Alzheimer's blood marker.

Preprint: cohort study of 163 peopleAlzheimer's disease

Paper

AAIC 2025 Abstract9 Jan