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The new blood-based tools estimate senescence gene activity to predict incident diseases, all-cause mortality, and clinical treatment responses.The new blood-based tools estimate senescence gene activity to predict incident diseases, all-cause mortality, and clinical treatment responses.
In over 1.8 million Japanese adults, the highest quartile of estimated sdLDL-C carried an ASCVD hazard ratio of 1.25 compared with the lowest.In over 1.8 million Japanese adults, the highest quartile of estimated sdLDL-C carried an ASCVD hazard ratio of 1.25 compared with the lowest.
A Global Burden of Disease analysis across 204 countries estimated 56.0 million prevalent heart failure cases in 2023, with rates generally increasing with age.A Global Burden of Disease analysis across 204 countries estimated 56.0 million prevalent heart failure cases in 2023, with rates generally increasing with age.
Hospital-recorded alcohol use disorder was linked to all-cause dementia with a hazard ratio of 3.73 compared with controls, peaking before age 70.Hospital-recorded alcohol use disorder was linked to all-cause dementia with a hazard ratio of 3.73 compared with controls, peaking before age 70.
Baseline TyG-CVAI predicted follow-up frailty index with a standardized β of 0.165, compared with a standardized β of 0.035 for the reverse path.Baseline TyG-CVAI predicted follow-up frailty index with a standardized β of 0.165, compared with a standardized β of 0.035 for the reverse path.
A phenome-wide study of 367,757 All of Us participants linked APOE alleles to 27 phenotypes, finding ancestry-specific risks for dementia and fatty liver disease.A phenome-wide study of 367,757 All of Us participants linked APOE alleles to 27 phenotypes, finding ancestry-specific risks for dementia and fatty liver disease.
Across six months, 46.3% of institutionalized older adults stayed stable, 34.4% showed gradual recovery, and 19.3% experienced progressive deterioration.Across six months, 46.3% of institutionalized older adults stayed stable, 34.4% showed gradual recovery, and 19.3% experienced progressive deterioration.
In 5,535 women aged 70 and older, endogenous estradiol concentrations showed no association with major cardiovascular events or all-cause mortality over 4.5 years of…In 5,535 women aged 70 and older, endogenous estradiol concentrations showed no association with major cardiovascular events or all-cause mortality over 4.5 years of follow-up.
