There are 2 papers on AKT1 phosphorylation in aging research: 1 observational study in people, 1 in animals.
2 papers study it3 more mention it3 findings
See all 5 papers on AKT1 phosphorylation
“AKT phosphorylation was associated with the global AD pathology score (p = 0.001).”
- Humans1
- Animals1
Upstream
1Diabetes mellitus
no changein humans1
1 study
Diabetes mellitus
no changein humans1
Diabetes mellitus was not clearly linked with AKT1 phosphorylation in humans.
“Brain insulin receptor substrate-1 (IRS1) phosphorylation (pS307 IRS1/total IRS1) and serine/threonine-protein kinase (AKT) phosphorylation (pT308 AKT1/total AKT1) were similar in persons with or without diabetes.”
Humansmiddle frontal gyrus cortex
Brain Insulin Signaling, Alzheimer Disease Pathology, and Cognitive Function
Annals of neurology
Associations
2Global cognitive function
downin humans1
1 study
Global cognitive function
downin humans1
AKT1 phosphorylation is associated with global cognitive function in humans (adjusted regression analyses) (estimate = -0.212, standard error = 0.097; p = 0.031).
“normalized pT308 AKT1 was associated with a lower level of global cognitive function (estimate = -0.212, standard error = 0.097; p = 0.031).”
Humansadjusted regression analysesmiddle frontal gyrus cortex
Brain Insulin Signaling, Alzheimer Disease Pathology, and Cognitive Function
Annals of neurology
Global Alzheimer disease pathology score
upin humans1
1 study
Global Alzheimer disease pathology score
upin humans1
AKT1 phosphorylation is associated with global Alzheimer disease pathology score in humans (adjusted regression analyses) (p = 0.001).
“AKT phosphorylation was associated with the global AD pathology score (p = 0.001).”
Humansadjusted regression analysesmiddle frontal gyrus cortex
Brain Insulin Signaling, Alzheimer Disease Pathology, and Cognitive Function
Annals of neurology