Aging indicators raise the risk of cardiovascular disease mortality in humans (96% higher risk (95% CI 47%–160%)).
“those exhibiting all indicators experienced a 81% (95% confidence interval, 59%–107%), 96% (47%–160%), 55% (26%–91%), and 114% (73%-165%) higher risk of all-cause, cardiovascular disease, cancer, and other causes of premature mortality”
Humansexhibiting all four indicators vs none13.74 yearsn = 369,741
Aging indicators raise the risk of premature mortality in humans (81% higher risk (95% CI 59%–107%)).
“those exhibiting all indicators experienced a 81% (95% confidence interval, 59%–107%), 96% (47%–160%), 55% (26%–91%), and 114% (73%-165%) higher risk of all-cause, cardiovascular disease, cancer, and other causes of premature mortality”
Humansexhibiting all four indicators vs none13.74 yearsn = 369,741
A computational analysis of single-cell gene activity data predicted increasingly different responses to disrupting the same gene at older ages.A computational analysis of single-cell gene activity data predicted increasingly different responses to disrupting the same gene at older ages.
Preprint: computational study of cells from humans, mice, flies and wormsMechanisms
Limit: Responses to actual gene disruptions were not measured
In UK Biobank participants, higher birthweight was associated with slower aging in 11 organs, while breastfeeding was linked to slower intestine and adrenal aging.In UK Biobank participants, higher birthweight was associated with slower aging in 11 organs, while breastfeeding was linked to slower intestine and adrenal aging.
Blood proteins statistically accounted for 0.5 to 50.7% of the risk associated with biological aging measures.Blood proteins statistically accounted for 0.5 to 50.7% of the risk associated with biological aging measures.
In 6,896 adults, the index scored 0.893 for predicting death within three years, outperforming three existing age and health measures.In 6,896 adults, the index scored 0.893 for predicting death within three years, outperforming three existing age and health measures.
Mean excursion amplitude was approximately 40 bpm at age 40 versus 32 bpm at 80; duration was approximately 90 versus 104 minutes, respectively.Mean excursion amplitude was approximately 40 bpm at age 40 versus 32 bpm at 80; duration was approximately 90 versus 104 minutes, respectively.