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Aggrecan and collagen type II production

Biomarker

1 paper1 finding

  • Humans1

Interventions

1

NSC140905

upin cells1

1 study

  1. NSC140905 increases aggrecan and collagen type II production in cells.

    “suppressing GATA4 expression in old chondrocytes, through either siRNA or a small-molecule inhibitor NSC140905, increased the production of aggrecan and collagen type II”

    Cellschondrocyte

    Aging-associated Increase of GATA4 levels in Articular Cartilage is Linked to Impaired Regenerative Capacity of Chondrocytes and Osteoarthritis

    eLife24 Sep 2025Preprint

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