In sorted cell populations, a machine-learning model found age-associated shifts in DNA marks towards a developmental family that includes connective-tissue cells.In sorted cell populations, a machine-learning model found age-associated shifts in DNA marks towards a developmental family that includes connective-tissue cells.
An analysis of adult human brain RNA data found age-linked patterns in the mix of RNA versions that persisted after accounting for each gene’s total RNA amount.An analysis of adult human brain RNA data found age-linked patterns in the mix of RNA versions that persisted after accounting for each gene’s total RNA amount.
Keeping immune cells in mouse tissues or increasing their numbers produced clusters across several organs without associated signs of disease.Keeping immune cells in mouse tissues or increasing their numbers produced clusters across several organs without associated signs of disease.
An observational analysis of 2,609 apparently healthy people linked the balance of two memory immune-cell groups to healthy and disease-associated aging patterns.An observational analysis of 2,609 apparently healthy people linked the balance of two memory immune-cell groups to healthy and disease-associated aging patterns.
Activating reprogramming factors for 16 days in old mice reduced DNA damage, improved blood reconstitution, and dampened transposable element activity.Activating reprogramming factors for 16 days in old mice reduced DNA damage, improved blood reconstitution, and dampened transposable element activity.
In aged roundworms, a low dose of zinc restored organismal zinc after an approximately 90% drop in zinc-to-sulfur ratio, improving healthspan and stress resistance.In aged roundworms, a low dose of zinc restored organismal zinc after an approximately 90% drop in zinc-to-sulfur ratio, improving healthspan and stress resistance.