Age-associated alterations in chromatin accessibility and histone modifications

1. Age-associated alterations in DNA methylation is associated with age-associated alterations in chromatin accessibility and histone modifications in humans.

   “our integrative genome-wide analysis revealed only limited association between age-associated epigenetic alterations in DNA methylation, chromatin accessibility, and histone modifications”

   HumansOnly limited association across epigenetic layers

   Genome-wide multi-layered epigenomic profiling across human aging

   bioRxiv (Cold Spring Harbor Laboratory)·27 Jul 2026Preprint

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