Age acceleration
Biomarker2 papers6 findings
Preprints associate age acceleration with organ biology in humans and report cancer-associated increases in computational comparisons of tumour and normal tissue. An in-silico preprint using Stacy-GB also associates age acceleration with multiple sclerosis, HIV infection, ischaemic heart disease and Werner syndrome.
- In silico2
Upstream
1Cancer
upin silico1
1 study
Cancer
upin silico1
Cancer increases age acceleration in silico (44 of 56 comparisons).
“Across the 56 cancer type clock combinations, tumor tissues showed higher average AA than normal tissues in 44 comparisons.”
In silicoin tumor vs normal tissues across 56 cancer type clock combinationsn = 5,528
Epigenetic Clocks Reveal Age Acceleration and Shared Methylation Remodeling Across Cancers · bioRxiv · 28 Aug 2026 · Preprint
Associations
5Organ biology
mixedin humans1
1 study
Organ biology
mixedin humans1
Age acceleration is associated with organ biology in humans.
Humansin 14 organs
Organ age acceleration and mortality risk reflect distinct biological processes · Research Square · 30 Sep 2026 · Preprint
Werner syndrome
upin silico1
1 study
Werner syndrome
upin silico1
Age acceleration is associated with Werner syndrome in silico.
In silicoestimated by Stacy-GB
Physics-Informed Modeling of Biological Aging through DNA Methylation Entropy · bioRxiv · 20 Aug 2026 · Preprint
Multiple sclerosis
upin silico1
1 study
Multiple sclerosis
upin silico1
Age acceleration is associated with multiple sclerosis in silico.
In silicoestimated by Stacy-GB
Physics-Informed Modeling of Biological Aging through DNA Methylation Entropy · bioRxiv · 20 Aug 2026 · Preprint
HIV infection
upin silico1
1 study
HIV infection
upin silico1
Age acceleration is associated with HIV infection in silico.
In silicoestimated by Stacy-GB
Physics-Informed Modeling of Biological Aging through DNA Methylation Entropy · bioRxiv · 20 Aug 2026 · Preprint
Ischemic heart disease
upin silico1
1 study
Ischemic heart disease
upin silico1
Age acceleration is associated with ischemic heart disease in silico.
In silicoestimated by Stacy-GB
Physics-Informed Modeling of Biological Aging through DNA Methylation Entropy · bioRxiv · 20 Aug 2026 · Preprint
Funding
National Institute on AgingUS$1.2mNational Institute of Environmental Health SciencesUS$588k3 grants since 2022
Latest
154Gap between predicted and actual age linked to death risk
In independent test samples, age estimates from Hungarian medical histories were off by an average of 7.78 years compared with actual ages.In independent test samples, age estimates from Hungarian medical histories were off by an average of 7.78 years compared with actual ages.
Sweet-tooth preferences were linked to higher dementia risk
The sweet-tooth group had a 79% higher dementia risk than the group labelled health-aligned in a prospective cohort study.The sweet-tooth group had a 79% higher dementia risk than the group labelled health-aligned in a prospective cohort study.
Hormone therapy linked to lower breast cancer mortality
Compared with never-users, hormone therapy ever-users had adjusted hazard ratios, which compare event rates over time, of 0.72 for breast cancer death…Compared with never-users, hormone therapy ever-users had adjusted hazard ratios, which compare event rates over time, of 0.72 for breast cancer death and 1.17 for diagnosis.
Biological aging and frailty linked to thinner central retinas
Blood metabolic profiles statistically accounted for 81.14% of the link with one biological age measure, compared with 19.92% for another and 32.27%…Blood metabolic profiles statistically accounted for 81.14% of the link with one biological age measure, compared with 19.92% for another and 32.27% for frailty.
Blood protein clock tracks shifts in health risks over time
In an observational study of 4,100 people, accelerated blood protein aging tracked worsening kidney function, blood lipid imbalances, and a higher…In an observational study of 4,100 people, accelerated blood protein aging tracked worsening kidney function, blood lipid imbalances, and a higher risk of death.
Faster biological aging linked to early colorectal adenocarcinoma
In Korean adults under 50, risk of early-onset colorectal adenocarcinoma was 93% higher in those with accelerated biological aging than in those…In Korean adults under 50, risk of early-onset colorectal adenocarcinoma was 93% higher in those with accelerated biological aging than in those without it.
Biological aging and heart health link to lung disease risk
A study of 181,955 UK Biobank participants linked accelerated biological aging and lower cardiovascular health to higher risks of chronic respiratory…A study of 181,955 UK Biobank participants linked accelerated biological aging and lower cardiovascular health to higher risks of chronic respiratory diseases.
Blood cell composition explains substantial variation in DNA methylation age
Cell counts explain less variation in age acceleration and only modestly affect its links to mortality and 176 incident health outcomes.Cell counts explain less variation in age acceleration and only modestly affect its links to mortality and 176 incident health outcomes.