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Targeted RNA delivery alleviates bone loss in mice
In a mouse model of osteoporosis caused by ovary removal, bone-targeted engineered vesicles preserved bone structure and reduced bone-breakdown activity without causing…In a mouse model of osteoporosis caused by ovary removal, bone-targeted engineered vesicles preserved bone structure and reduced bone-breakdown activity without causing systemic toxicity.
Mouse studyBones and joints
Who was studiedFemale mice, six weeks, against mice receiving the non-targeted formulation
What changedMice receiving bone-targeted RNA delivery retained more trabecular bone than mice receiving the non-targeted formulation
The catchOnly 5 mice per group in the bone-loss experiment