3 papers3 findings
Major depressive disorder
upin humans1
Major depressive disorder increases accelerated brain aging in humans (67 gray matter regions).
“revealing accelerated aging in 66 gray matter regions in BD and 67 in MDD”
Humansin major depressive disordergray matter
Psychological medicineAug 29, 2025
Bipolar disorder
upin humans1
Bipolar disorder increases accelerated brain aging in humans (66 gray matter regions).
“revealing accelerated aging in 66 gray matter regions in BD and 67 in MDD”
Humansin bipolar disordergray matter
Psychological medicineAug 29, 2025
P-wave duration
downin humans1
P-wave duration is associated with accelerated brain aging in humans.
“PWD is inversely associated with accelerated brain aging in the sensorimotor, frontoparietal, ventral attention, and dorsal attention networks”
Humansabsence of overt cardiac diseases
Subclinical variations on ECG and their associations with structural brain aging networks
medRxiv : the preprint server for health sciencesMar 19, 2024Preprint
National Institute on AgingUS$500kNational Institute of Mental HealthUS$1.2m
Using Artificial Intelligence to Identify Accelerated Brain Aging in World Trade Center Responders
National Institute on AgingState University New York Stony BrookUS$250k2021–2024
Depression and accelerated brain aging: A PET imaging study
National Institute of Mental HealthYale UniversityUS$1.2m2019–2025
A three-region model scored 0.81 versus 0.79 for a whole-brain model on a measure of how well it ranked death risk.A three-region model scored 0.81 versus 0.79 for a whole-brain model on a measure of how well it ranked death risk.
The gap between scan-estimated and actual age exceeded age-matched controls by 7.64 years in schizophrenia and 7.61 years in frontotemporal dementia.The gap between scan-estimated and actual age exceeded age-matched controls by 7.64 years in schizophrenia and 7.61 years in frontotemporal dementia.