18F-FDG uptake

1. Hearing aids increase 18F-FDG uptake in humans.

   “Database analysis identified 5 regions associated with increased 18 F‐FDG uptake between baseline and 12 months in the early (group A) compared to late (group B) intervention cohort.”

   Human trialearly compared to late hearing aid interventionbrain12 monthsn = 28

   HearCog Trial‐ Findings from FDG‐PET

   AAIC 2025 abstract·25 Dec 2025

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1. Cannabidiol increases 18F-FDG uptake in mice.

   “CBD‐females had higher [ 18 F]FDG uptake than vehicle‐females at 18 months ( p = 0.024).”

   Animalsin 3xTg-AD micewhole brain20 mg/kg30 daysfemales

   Evaluation of the effect of cannabidiol treatment on [ ¹⁸ F]FDG and [ ¹¹ C]PK11195 uptake in an animal model for Alzheimer's disease

   AAIC 2025 abstract·24 Dec 2025

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1. Lithium carbonate decreases 18F-FDG uptake in mice.

   “Regarding [ 18 F]FDG, its uptake also increased in Ts‐Ct from 2 to 14 months ( p <0.001) and was higher than in Eup‐Li and Ts‐Li ( p <0.05).”

   Animalsin Ts65Dn mice compared to untreated controlsbrain0.25 mg/kg

   Evaluation of lithium carbonate treatment in a mouse model of Down syndrome using positron emission tomography

   AAIC 2025 abstract·24 Dec 2025

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