Phase 1/2Active, not recruiting
Fisetin to Improve Vascular Function in Older Adults
Clinical Translation of Senolytic Therapy With Fisetin to Improve Vascular Function in Older Adults
- Sponsor
- University of Colorado, Boulder (Academic or other)
- Enrolment
- 70 planned
- Conditions
- Aging; Endothelial Dysfunction; Arterial Stiffness
- Interventions
- Fisetin; Placebo
- Ages
- older adults
- Registry
- NCT06133634
From the registry
This is a pilot clinical trial to test the efficacy of intermittent treatment with the flavonoid compound fisetin for improving vascular endothelial function and reducing aortic stiffness in older adults. This trial will also determine the potential mechanisms by which fisetin may improve vascular function, including by decreasing mitochondrial oxidative stress, cellular senescence and senescence-associated secretory phenotype (SASP) factors in circulation. Lastly, safety, tolerability and adherence of fisetin treatment will be assessed.
Primary outcomes
- Change from baseline in endothelial function at 1 month