No phaseActive, not recruiting
The Genomic Medicine at VA Study (GenoVA)
Pragmatic Randomized Trial of Polygenic Risk Scoring for Common Diseases in Primary Care
- Sponsor
- Boston VA Research Institute, Inc. (Academic or other)
- Enrolment
- 1,071 enrolled
- Conditions
- Coronary Artery Disease; Atrial Fibrillation; Type 2 Diabetes; Colorectal Cancer; Breast Cancer; Prostate Cancer
- Interventions
- Polygenic risk score (PRS)
- Ages
- adults, older adults
- Registry
- NCT04331535
From the registry
This trial will determine the clinical effectiveness of polygenic risk score testing among patients at high genetic risk for at least one of six diseases (coronary artery disease, atrial fibrillation, type 2 diabetes mellitus, colorectal cancer, breast cancer, or prostate cancer), measured by time-to-diagnosis of prevalent or incident disease over 24 months.
Primary outcomes
- Time-to-new diagnosis of common complex disease