140 results
In laboratory experiments, roflumilast and rolipram lengthened roundworm lifespan by activating a signalling pathway that improved mitochondrial function and alleviated…In laboratory experiments, roflumilast and rolipram lengthened roundworm lifespan by activating a signalling pathway that improved mitochondrial function and alleviated oxidative stress.
In 7,028 patients tested separately, the score distinguished those who died from survivors with a prediction-performance measure of 0.78.In 7,028 patients tested separately, the score distinguished those who died from survivors with a prediction-performance measure of 0.78.
In two prospective cohorts, each standard deviation increase in estimated glucose disposal rate was associated with a 40% lower risk of multiple cardiometabolic diseases.In two prospective cohorts, each standard deviation increase in estimated glucose disposal rate was associated with a 40% lower risk of multiple cardiometabolic diseases.
Each one-unit increase in log10 lipid accumulation product was associated with a cardiometabolic multimorbidity hazard ratio of 3.03 (95% CI 2.33–3.93).Each one-unit increase in log10 lipid accumulation product was associated with a cardiometabolic multimorbidity hazard ratio of 3.03 (95% CI 2.33–3.93).
A 36-metabolite signature mediated an estimated 18.5% of the association between frailty and incident coronary artery disease over a median 14.8-year follow-up.A 36-metabolite signature mediated an estimated 18.5% of the association between frailty and incident coronary artery disease over a median 14.8-year follow-up.
Blocking the prostaglandin E2 pathway or targeting cellular senescence reduces uterine scarring and improves tissue repair in mouse models of cesarean defects.Blocking the prostaglandin E2 pathway or targeting cellular senescence reduces uterine scarring and improves tissue repair in mouse models of cesarean defects.
In 63,083 UK adults, short sleep had a hazard ratio of 1.16, irregular sleep 1.21, and low sleep efficiency 1.23 for incident osteoporosis.In 63,083 UK adults, short sleep had a hazard ratio of 1.16, irregular sleep 1.21, and low sleep efficiency 1.23 for incident osteoporosis.
In 23,790 older adults, higher small HDL levels tracked lower dementia risk (hazard ratios 0.89 to 0.91), while very large HDL tracked higher risk (1.10 to 1.14).In 23,790 older adults, higher small HDL levels tracked lower dementia risk (hazard ratios 0.89 to 0.91), while very large HDL tracked higher risk (1.10 to 1.14).