Tumor Suppressors Are Longevity Genes: A Conceptual Shift in Cancer Biology

More on p53–p21 pathway

• Human protein variant eased signs of progeria in mice

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• New protein form pushed lab-grown cells to stop dividing

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• Transcriptomic longevity modules predict life span-extending compounds in roundworms

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• A distinct p21-driven macrophage senotype accumulates during aging and liver disease

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