Multi-Omics Comes of Age: Immune Profiling of Human Aging

A recent study by Gong et al. maps peripheral immune aging using multi-omic profiling and longitudinal influenza vaccination across adults aged 25-90+, revealing midlife (55-65) immune remodeling. Analyses of PBMCs, proteomics, and cell function show early dysregulation before aging, highlighting links to later disease susceptibility before inflammaging.