A receptor for glycation end products (RAGE) is a key transmitter between garb-aging and inflammaging

A receptor for glycation end products (RAGE) plays a key role in the pathogenesis of many chronic diseases associated with aging. Acting as a multi-ligand sensor, RAGE is able to bind a wide range of stimuli, which fuels inflammation. This makes it a key link between garb-aging and inflammaging. We propose that RAGE functions as the missing molecular link between garb-aging, the progressive buildup of biological waste, and inflammaging, the chronic inflammatory state that drives degenerative disorders. This review summarizes current knowledge on RAGE structure, ligands, and signaling, highlighting its involvement in diabetes, cardiovascular, neurodegenerative, and inflammatory diseases, as well as therapeutic strategies targeting RAGE. By nominating RAGE as a central receptor of garb-aging, we outline new perspectives for combating age-associated pathologies.