Zenodo
Nicotinamide Riboside for Mitochondrial Rescue in Residual HSCs
PreprintInterventions
Abstract
Nicotinamide riboside enhances NAD+ biosynthesis, improving mitochondrial function in metabolically compromised hematopoietic stem cells. Enhanced NAD+/NADH ratios activate SIRT1/SIRT3 pathways, promoting HSC quiescence maintenance and resistance to further damage.
- Nicotinamide riboside
- NAD+ metabolism
- Sirtuin signalling
- Mitochondrion
- HSC quiescence maintenance
- NAD/NADH ratio
The paper
MedicOath
Zenodo, 28 Apr 2026, Open access, CC0, Preprint, not peer-reviewed
