Preprint

telomere: one bounded, context-dependent signal across receipts

Preprint: reviewBiomarkers
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Abstract

Researka accepted publication: 5656b611-9e22-4b55-bce0-289625f554db Source submission: b8f3b029-82b6-44d1-8242-c025db36405f This receipt-backed scoping note has one bounded signal: telomere shows context-dependent, not uniformly convergent associations across this 5-source primary/review bundle (2017-2023). Grouped by direction, directionally favorable: 1 receipt(s) | other/mixed: 4 receipt(s). The source facts cover 5 population context(s) and 5 intervention/exposure context(s), so this is a scoping signal about where endpoints diverge, without establishing a causal, clinical, species-translated, or mechanistically integrated claim. The listed effect sizes remain source-specific across endpoints and populations; they are not pooled or averaged. Concrete source-level examples: This revealed a significant effect of treatment on telomere dynamics (d=0.36); The liver disease cohort (HR 1.22, 95% CI 0.99-1.51) had increased mortality risk with shorter TL; but raised risk of cancer (OR = 1.11, 95% CI: 1.06-1.16).