Estrogen exposure estimates linked to longer life expectancy

Higher exposure estimates, particularly total exposure, were generally associated with less advanced biological aging and longer estimated life expectancy. Longer reproductive lifespan and higher total exposure estimates were generally linked to lower risks of death from any cause, cardiovascular disease and respiratory disease across both cohorts. In UK Biobank, longer reproductive lifespan and higher estimated exposure to estrogen produced within the body were associated with higher incidence of cancer of the uterine lining. All three exposure indices were associated with higher breast cancer incidence.