Endogenous estrogen exposure

Intervention1 paper1 finding

C · W · M · H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper that declares the maker’s interest.

1 lab in 1 country
  • Humans1

Associations

1

Mortality

downin humans1HR 0.19

1 study
  1. Endogenous estrogen exposure lowers the risk of mortality in humans (HR: 0.19; 95% CI: 0.05-0.76).

    Humansmetabolically healthy overweight/obesity18-yearfemales

    Endogenous Estrogen Exposure and All-Cause Mortality Among Women with Overweight or Obesity According to Metabolic Health Status: Insights from an 18-Year Prospective Cohort Study · International journal of women's health · 10 Sep 2026

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