Reproductive lifespan

3 papers5 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

3 independent labs in 3 countries

Funders: China Postdoctoral Science Foundation and 4 more

Humans3

Associations

5

Cerebral small vessel disease

downin humans1OR 0.9

1 study

Reproductive lifespan lowers the risk of cerebral small vessel disease in humans (OR=0.90 [95%CI 0.83-0.98]).
“Longer reproductive span (OR=0.90 [95%CI 0.83-0.98]) and MHT use (OR=0.43 [95% CI 0.20-0.92]) were linked to lower SVD burden”
Humansbrainfemalesn = 352
Reproductive lifespan and hormonal therapy in relation to later-life neurovascular health: A population-based study of women in the Gothenburg H70-1944 Birth Cohort
medRxiv : the preprint server for health sciences5 Feb 2026Preprint

More on Cerebral small vessel disease

Cognitive function

upin humans1

1 study

Reproductive lifespan is associated with cognitive function in humans (adjusted β = 0.15; 95% CI: 0.03, 0.26).
“Women with longer reproductive lifespans (>38 years) reported significantly higher cognitive scores compared to those in the shortest tertile (adjusted β = 0.15; 95% CI: 0.03, 0.26).”
Humansfemalesn = 1,435
Length of Reproductive Lifespan and Late-Life Cognitive Function Among U.S. Women: Evidence from NHANES 2011-2014
GSA 2025 abstract31 Dec 2025

Cardiovascular disease

downin humans1

1 study

Reproductive lifespan lowers the risk of cardiovascular disease in humans (aOR 0.954; 95%CI 0.946, 0.962).
“hypertension (aOR 0.969; 95%CI 0.962, 0.975) and CVD (aOR 0.954; 95%CI 0.946, 0.962).”
Humansfemalesn = 35,498
Reproductive history and cardiometabolic disease: the role of endogenous estrogen exposure across the lifespan in postmenopausal women
BMC women's health21 Oct 2025

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Hypertension

downin humans1

1 study

Reproductive lifespan lowers the risk of hypertension in humans (aOR 0.969; 95%CI 0.962, 0.975).
“each additional year of reproductive lifespan was associated with lower risks of diabetes (aOR 0.971; 95%CI 0.961, 0.982), hypertension (aOR 0.969; 95%CI 0.962, 0.975)”
Humansfemalesn = 35,498
Reproductive history and cardiometabolic disease: the role of endogenous estrogen exposure across the lifespan in postmenopausal women
BMC women's health21 Oct 2025

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Diabetes

downin humans1

1 study

Reproductive lifespan lowers the risk of diabetes in humans (aOR 0.971; 95%CI 0.961, 0.982).
“each additional year of reproductive lifespan was associated with lower risks of diabetes (aOR 0.971; 95%CI 0.961, 0.982)”
Humansfemalesn = 35,498
Reproductive history and cardiometabolic disease: the role of endogenous estrogen exposure across the lifespan in postmenopausal women
BMC women's health21 Oct 2025

More on Diabetes

Latest

2 in 12 months

medRxiv12 Feb

Reproductive lifespan and hormonal therapy in relation to later-life neurovascular health: A population-based study of women in the Gothenburg H70-1944 Birth Cohort

Preprint: cohort study of 352 peoplePopulations

GSA 2025 Abstract3 Jan

Length of Reproductive Lifespan and Late-Life Cognitive Function Among U.S. Women: Evidence from NHANES 2011-2014

Cross-sectional study of 1,435 peoplePopulations

BMC Women's Health22 Oct

Reproductive history and cardiometabolic disease: the role of endogenous estrogen exposure across the lifespan in postmenopausal women

Cohort study of 35,498 peopleCardiometabolic disease