ant-1.1

ant-1.1 improves healthspan in worms.

“combining a daf-2 hypomorph with adenine nucleotide translocase 1.1 (ant-1.1) knockdown leads to a four-fold increase in lifespan and a concomitant healthspan increase.”

Model organismscombined with daf-2 hypomorph

Combined Downregulation of Insulin and Mitochondrial Signaling Leads to Synergistic Life- and Healthspan Extension in Caenorhabditis Elegans · GSA 2025 abstract · 31 Dec 2025

ant-1.1 extends lifespan in worms (four-fold).

“combining a daf-2 hypomorph with adenine nucleotide translocase 1.1 (ant-1.1) knockdown leads to a four-fold increase in lifespan”

Model organismscombined with daf-2 hypomorph

Combined Downregulation of Insulin and Mitochondrial Signaling Leads to Synergistic Life- and Healthspan Extension in Caenorhabditis Elegans · GSA 2025 abstract · 31 Dec 2025