The Myeloid Differentiation Factor‐2 Inhibitor Alleviates Brain Mitochondrial Oxidative Stress Without Improving Cognitive Impairment in Aged‐Female Rats
AAIC 2025 Abstract
Abstract
Background: Therapeutic approaches that aimed to improve brain mitochondrial function, could potentially mitigate age‐related cognitive impairments. The myeloid differentiation factor‐2 (MD2) inhibitor, L6H2, has been shown to alleviate brain mitochondrial dysfunction and cognitive deficits in obese rats.
- L6H2
- Mitochondrial division inhibitor-1
- LY96
- Oxidative stress and ROS signalling
- Cognitive impairment
- Rats
