L6H2

1. L6H2 has no effect on cognitive impairment in rats.

   “This indicates cognitive impairment in the aged‐female rats, with neither treatment showing improvement.”

   Animalsbrain40 mg/kg/day2 weeksfemales

   The Myeloid Differentiation Factor‐2 Inhibitor Alleviates Brain Mitochondrial Oxidative Stress Without Improving Cognitive Impairment in Aged‐Female Rats · AAIC 2025 abstract · 23 Dec 2025

Cognitive impairment →

1. L6H2 improves mitochondrial membrane potential in rats.

   “and an improvement in mitochondrial membrane potential, without affecting mitochondrial swelling, compared to the control group”

   Animalsbrain40 mg/kg/day2 weeksfemales

   The Myeloid Differentiation Factor‐2 Inhibitor Alleviates Brain Mitochondrial Oxidative Stress Without Improving Cognitive Impairment in Aged‐Female Rats · AAIC 2025 abstract · 23 Dec 2025

Mitochondrial membrane potential →

1. L6H2 decreases mitochondrial ROS in rats.

   “Only MD2‐treated rats exhibited a significant reduction in brain mitochondrial reactive oxygen species (ROS) levels”

   Animalsbrain40 mg/kg/day2 weeksfemales

   The Myeloid Differentiation Factor‐2 Inhibitor Alleviates Brain Mitochondrial Oxidative Stress Without Improving Cognitive Impairment in Aged‐Female Rats · AAIC 2025 abstract · 23 Dec 2025

Mitochondrial ROS →