Single-cell multiomic QTL mapping reveals state-dependent genetic regulation and associated gene during cellular senescence
bioRxiv
Abstract
How cellular senescence reshapes inherited regulatory effects across chromatin and transcription, and eventually contribute to non-coding risk loci of complex diseases, remains elusive. We generated single-cell multiome ATAC-RNA profiles from proliferating and replicatively senescent primary HUVECs derived from 100 genotyped donors.
The paper
Yi X, Wang X, Liu K et al.
bioRxiv · 21 Sep 2026 · CC BY · Preprint, not peer-reviewed
