Hierarchical and context-dependent GR-MR signalling governs endogenous corticosteroid decoding in the heart
bioRxiv
Abstract
Endogenous corticosteroids bind both the glucocorticoid receptor (GR) and mineralocorticoid receptor (MR), yet how this shared ligand input is decoded in the heart remains unclear. Previous work established that corticosterone suppresses postnatal cardiomyocyte proliferation through GR.
The paper
Sacchi F, Boriati S, Caliandro R et al.
bioRxiv · 11 Sep 2026 · CC BY · Preprint, not peer-reviewed
