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Wortmannin

Intervention

2 papers4 findings

PubChemChEBIMeSH

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

  • 2 independent labs in 1 country
  • 1 finding against
  • Funders: National Institute of General Medical Sciences and 2 more
  • Animals1
  • Model organisms1

Outcomes

3

Lifespan

downin flies1upin mice1

2 studies

  1. Wortmannin shortens lifespan in flies.

    “Rapamycin, spermidine and wortmannin all had significant life-shortening effects at the highest doses tested.”

    Model organismsy w strainhighest doses testedmales

    Effects of Target of Rapamycin and Phosphatidylinositol 3-Kinase Inhibitors and Other Autophagy-Related Supplements on Life Span in y w Male Drosophila melanogaster

    International journal of molecular sciences26 Oct 2024

  2. Wortmannin extends lifespan in mice (nearly doubled at 60% survival).

    “nearly doubled the lifespan of Pcmt1(-/-) at 60% survival of the original population”

    AnimalsPcmt1(-/-) miceoral

    Wortmannin reduces insulin signaling and death in seizure-prone Pcmt1-/- mice

    PloS one5 Oct 2012

PI3K–AKT signalling

downin mice1

1 study

  1. Wortmannin inhibits PI3K–AKT signalling in mice.

    “Immunoblotting revealed significant decreases in phosphorylation of Akt, PDK1, and mTOR in Pcmt1(-/-) mice”

    AnimalsPcmt1(-/-) micebrain

    Wortmannin reduces insulin signaling and death in seizure-prone Pcmt1-/- mice

    PloS one5 Oct 2012

More on PI3K–AKT signalling

Brain size

downin mice1

1 study

  1. Wortmannin decreases brain size in mice (to within 6% of wild-type DMSO controls).

    “Oral wortmannin reduced the average brain size in the Pcmt1(-/-) animals to within 6% of the wild-type DMSO administered controls”

    AnimalsPcmt1(-/-) miceoralbrain

    Wortmannin reduces insulin signaling and death in seizure-prone Pcmt1-/- mice

    PloS one5 Oct 2012

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