Water restriction

1. Water restriction increases REN in O. cuniculus (1.7-fold).

   “1.7-fold increase of kidney renin gene expression in the young rabbits”

   Animalswater volume restriction protocolkidneyn = 22

   Proteomic analysis reveals that aging rabbit vocal folds are more vulnerable to changes caused by systemic dehydration

   BMC genomics·Nov 21, 2022

More on REN

1. Water restriction increases cardiac fibrosis in mice.

   “renal glomerular injury, and the development of cardiac fibrosis.”

   Animals

   Suboptimal hydration remodels metabolism, promotes degenerative diseases, and shortens life

   JCI insight·Sep 5, 2019

1. Water restriction impairs neuromuscular coordination in mice.

   “water restriction yields stable metabolism remodeling toward metabolic water production with greater food intake and energy expenditure, an elevation of markers of inflammation and coagulation, accelerated decline of neuromuscular coordination”

   Animals

   Suboptimal hydration remodels metabolism, promotes degenerative diseases, and shortens life

   JCI insight·Sep 5, 2019

1. Water restriction shortens lifespan in mice.

   “We demonstrate that restricting the amount of drinking water shortens mouse lifespan”

   Animals

   Suboptimal hydration remodels metabolism, promotes degenerative diseases, and shortens life

   JCI insight·Sep 5, 2019