Tubeimoside i

1. Tubeimoside i decreases tissue damage in mice.

   “In vivo, TBMS1 improved motor function, reduced senescence markers, and alleviated tissue damage in both radiation-induced and naturally aged mouse models, without significant toxicity observed.”

   Animalsradiation-induced and naturally aged mouse models

   Tubeimoside Ⅰ targets sodium/potassium ATPase alpha 1 subunit to selectively eliminate senescent cells and alleviate aging-associated abnormalities

   Phytomedicine : international journal of phytotherapy and phytopharmacology·15 Apr 2026

1. Tubeimoside i decreases senescence markers in mice.

   “In vivo, TBMS1 improved motor function, reduced senescence markers, and alleviated tissue damage in both radiation-induced and naturally aged mouse models, without significant toxicity observed.”

   Animalsradiation-induced and naturally aged mouse models

   Tubeimoside Ⅰ targets sodium/potassium ATPase alpha 1 subunit to selectively eliminate senescent cells and alleviate aging-associated abnormalities

   Phytomedicine : international journal of phytotherapy and phytopharmacology·15 Apr 2026

More on Senescence markers

1. Tubeimoside i improves motor function in mice.

   “In vivo, TBMS1 improved motor function, reduced senescence markers, and alleviated tissue damage in both radiation-induced and naturally aged mouse models, without significant toxicity observed.”

   Animalsradiation-induced and naturally aged mouse models

   Tubeimoside Ⅰ targets sodium/potassium ATPase alpha 1 subunit to selectively eliminate senescent cells and alleviate aging-associated abnormalities

   Phytomedicine : international journal of phytotherapy and phytopharmacology·15 Apr 2026

1. Tubeimoside i induces apoptosis in mouse cells.

   “TBMS1 modulated ATP1A1 activity, leading to altered intracellular potassium dynamics and disruption of ion homeostasis, which contributed to mitochondrial dysfunction and apoptosis in senescent cells.”

   Cellssenescent cells

   Tubeimoside Ⅰ targets sodium/potassium ATPase alpha 1 subunit to selectively eliminate senescent cells and alleviate aging-associated abnormalities

   Phytomedicine : international journal of phytotherapy and phytopharmacology·15 Apr 2026

More on Apoptosis

1. Tubeimoside i impairs ion homeostasis in mouse cells.

   “TBMS1 modulated ATP1A1 activity, leading to altered intracellular potassium dynamics and disruption of ion homeostasis”

   Cellssenescent cells

   Tubeimoside Ⅰ targets sodium/potassium ATPase alpha 1 subunit to selectively eliminate senescent cells and alleviate aging-associated abnormalities

   Phytomedicine : international journal of phytotherapy and phytopharmacology·15 Apr 2026

1. Tubeimoside i decreases senescent cells in mouse cells.

   “We identified that TBMS1 is a senolytic agent.”

   Cells

   Tubeimoside Ⅰ targets sodium/potassium ATPase alpha 1 subunit to selectively eliminate senescent cells and alleviate aging-associated abnormalities

   Phytomedicine : international journal of phytotherapy and phytopharmacology·15 Apr 2026