Transient OSKM expression

1. Transient OSKM expression decreases senescence-associated secretory phenotype (SASP) in mice.

   “Partial reprogramming, involving transient OSKM expression, rejuvenates cells by resetting epigenetic clocks, reducing senescence-associated secretory phenotypes (SASPs), and improving mitochondrial function, as evidenced by lifespan extension in progeroid mouse models.”

   Reviewin progeroid mouse models

   Decoding Aging through iPSC Reprogramming: Advances and Challenges

   Aging and disease·5 May 2025

More on Senescence-associated secretory phenotype (SASP)

1. Transient OSKM expression extends lifespan in mice.

   “Partial reprogramming, involving transient OSKM expression, rejuvenates cells by resetting epigenetic clocks, reducing senescence-associated secretory phenotypes (SASPs), and improving mitochondrial function, as evidenced by lifespan extension in progeroid mouse models.”

   Reviewprogeroid mouse models

   Decoding Aging through iPSC Reprogramming: Advances and Challenges

   Aging and disease·5 May 2025