Topotecan

1. Topotecan increases UBE3A in mice.

   “topotecan treatment to HD mouse not only inhibits the expression of transgenic mutant huntingtin, but also at the same time induces the expression of Ube3a”

   Animalsin HD transgenic mousebrain

   Topoisomerase 1 inhibitor topotecan delays the disease progression in a mouse model of Huntington's disease

   Human molecular genetics·15 Jan 2017

More on UBE3A

1. Topotecan decreases insoluble mutant huntingtin load in mice.

   “topotecan treatment also significantly reduced insoluble mutant huntingtin load in the HD mouse brain.”

   Animalsin HD transgenic mousebrain

   Topoisomerase 1 inhibitor topotecan delays the disease progression in a mouse model of Huntington's disease

   Human molecular genetics·15 Jan 2017

More on Insoluble mutant huntingtin load

1. Topotecan improves motor behavioural abnormalities in mice.

   “treatment of topotecan, a brain-penetrating topoisomerase 1 inhibitor, to HD transgenic mouse considerably improved its motor behavioural abnormalities”

   Animalsin HD transgenic mouse

   Topoisomerase 1 inhibitor topotecan delays the disease progression in a mouse model of Huntington's disease

   Human molecular genetics·15 Jan 2017

1. Topotecan extends lifespan in mice.

   “treatment of topotecan, a brain-penetrating topoisomerase 1 inhibitor, to HD transgenic mouse considerably improved its motor behavioural abnormalities along with a significant extension of lifespan.”

   Animalsin HD transgenic mouse

   Topoisomerase 1 inhibitor topotecan delays the disease progression in a mouse model of Huntington's disease

   Human molecular genetics·15 Jan 2017