Insoluble mutant huntingtin load

1. Topotecan decreases insoluble mutant huntingtin load in mice.

   “topotecan treatment also significantly reduced insoluble mutant huntingtin load in the HD mouse brain.”

   Animalsin HD transgenic mousebrain

   Topoisomerase 1 inhibitor topotecan delays the disease progression in a mouse model of Huntington's disease

   Human molecular genetics·15 Jan 2017

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