Time since menopause

2 papers3 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

1 lab in 1 country

Funder: National Natural Science Foundation of China

Humans2

Outcomes

SCORE2

upin humans1

1 study

Time since menopause improves SCORE2 in humans (AUC 0.584 to 0.657).
“Adding TSM or the metabolomic signature to SCORE2 improved 10‐year risk discrimination (area under the curve 0.584 to 0.657 and 0.660, respectively)”
Humansfemalesn = 67,582
Integrating menopause duration and plasma metabolomics enhances cardiovascular risk stratification in aging women
npj aging6 Jan 2026

Associations

Cardiovascular disease

upin humans2HR 1.14

2 studies

Time since menopause raises the risk of cardiovascular disease in humans (HR 1.14, 95% CI 1.11-1.16 per 5-year increment).
“each 5-year increment in TSM (HR 1.14, 95% CI 1.11-1.16) and each 1-standard deviation increases in the metabolomic signature (HR 1.18, 95% CI 1.15-1.21) were independently associated with higher composite CVD risk”
Humansfemalesn = 67,582
Integrating menopause duration and plasma metabolomics enhances cardiovascular risk stratification in aging women
npj aging6 Jan 2026
Time since menopause raises the risk of cardiovascular disease in humans (HR 1.14, 95% CI 1.11–1.16).
“Each one-unit (5-year) increase in TSM (HR 1.14, 95% CI 1.11–1.16) and each 1-SD increase in the metabolomic signature (HR 1.18, 95% CI 1.15–1.21) were independently associated with elevated CVD risk”
Humansfemalesn = 67,582
Time Since Menopause Shapes Women's Metabolome and Cardiovascular Risk
AHA Scientific Sessions 2025 abstract3 Nov 2025