TSM-related metabolomic signature

1. TSM-related metabolomic signature mediates cardiovascular disease in humans (11.6%).

   “Mediation analysis indicated that 11.6% of the association between TSM and CVD was mediated by the metabolomic signature.”

   Humansassociation between TSM and CVDfemalesn = 67,582

   Time Since Menopause Shapes Women's Metabolome and Cardiovascular Risk

   AHA Scientific Sessions 2025 abstract·3 Nov 2025

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1. TSM-related metabolomic signature raises the risk of cardiovascular disease in humans (HR 1.18, 95% CI 1.15–1.21).

   “each 1-SD increase in the metabolomic signature (HR 1.18, 95% CI 1.15–1.21) were independently associated with elevated CVD risk after adjustment for confounders.”

   Humansfemalesn = 67,582

   Time Since Menopause Shapes Women's Metabolome and Cardiovascular Risk

   AHA Scientific Sessions 2025 abstract·3 Nov 2025

More on Cardiovascular disease