TSM-associated metabolomic signature

1. TSM-associated metabolomic signature improves SCORE2 in humans (AUC 0.584 to 0.660).

   “Adding TSM or the metabolomic signature to SCORE2 improved 10‐year risk discrimination (area under the curve 0.584 to 0.657 and 0.660, respectively)”

   Humansfemalesn = 67,582

   Integrating menopause duration and plasma metabolomics enhances cardiovascular risk stratification in aging women

   npj aging·6 Jan 2026

More on SCORE2

1. TSM-associated metabolomic signature raises the risk of cardiovascular disease in humans (HR 1.18, 95% CI 1.15-1.21 per 1-SD increase).

   “each 1-standard deviation increases in the metabolomic signature (HR 1.18, 95% CI 1.15-1.21) were independently associated with higher composite CVD risk”

   Humansfemalesn = 67,582

   Integrating menopause duration and plasma metabolomics enhances cardiovascular risk stratification in aging women

   npj aging·6 Jan 2026

More on Cardiovascular disease