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Tenon-mesenchymal stem cell complex

Intervention

1 paper4 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funders: Korea Health Industry Development Institute and 1 more
  • Cells1

Outcomes

4

Cellular metabolism

upin cells1

1 study

  1. Tenon-mesenchymal stem cell complex improves cellular metabolism in cells.

    “METn could repair DNA damage and improve cellular metabolism in senescent TDCs by releasing antisenescence factors.”

    CellsSenescent tendon-derived cellstendon-derived cell

    UC MSCs Educated Tenon (METn) Stimulates Tendon Regeneration Through Rejuvenation of the Complex and Tendon-Derived Cells (TDCs)

    Stem cells international10 Jul 2025

DNA damage

downin cells1

1 study

  1. Tenon-mesenchymal stem cell complex decreases DNA damage in cells.

    “METn could repair DNA damage and improve cellular metabolism in senescent TDCs by releasing antisenescence factors.”

    CellsSenescent tendon-derived cellstendon-derived cell

    UC MSCs Educated Tenon (METn) Stimulates Tendon Regeneration Through Rejuvenation of the Complex and Tendon-Derived Cells (TDCs)

    Stem cells international10 Jul 2025

Collagen fiber quantity and quality

upin cells1

1 study

  1. Tenon-mesenchymal stem cell complex increases collagen fiber quantity and quality in cells.

    “rejuvenated METn (TSC) had higher tenogenic marker expression, collagen fiber quantity, and quality than MSC-only or METc (TDC-MSC complex).”

    CellsFibrin 3D gel culture; compared with MSC-only or TDC-MSC complex

    UC MSCs Educated Tenon (METn) Stimulates Tendon Regeneration Through Rejuvenation of the Complex and Tendon-Derived Cells (TDCs)

    Stem cells international10 Jul 2025

Tenogenic marker expression

upin cells1

1 study

  1. Tenon-mesenchymal stem cell complex increases tenogenic marker expression in cells.

    “rejuvenated METn (TSC) had higher tenogenic marker expression, collagen fiber quantity, and quality than MSC-only or METc (TDC-MSC complex).”

    CellsFibrin 3D gel culture; compared with MSC-only or TDC-MSC complex

    UC MSCs Educated Tenon (METn) Stimulates Tendon Regeneration Through Rejuvenation of the Complex and Tendon-Derived Cells (TDCs)

    Stem cells international10 Jul 2025

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