Telomerase reactivation

1 paper5 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

1 lab in 1 country

Funder: National Cancer Institute

Animals1

Outcomes

Olfactory avoidance responses

upin mice1

1 study

Telomerase reactivation improves olfactory avoidance responses in mice.
“alleviation of hyposmia and recovery of innate olfactory avoidance responses.”
Animalsin late generation TERT-ER mice
Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice
Nature28 Nov 2010

Neurodegenerative disease

downin mice1

1 study

Telomerase reactivation decreases neurodegenerative disease in mice.
“Notably, somatic telomerase reactivation reversed neurodegeneration with restoration of proliferating Sox2(+) neural progenitors, Dcx(+) newborn neurons, and Olig2(+) oligodendrocyte populations.”
Animalsin late generation TERT-ER micebrain
Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice
Nature28 Nov 2010

Latest

Nature28 Nov